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Drug Information > Barbiturates

Drug Appearance:

Capsules of varying colors

Street Name(s):

Downers  Dolls  Reds  Tuinal  Rainbows
Yellows  Blues  Goofballs  M&Ms  Red Devils

Signs of Use:

User needing longer periods of rest or sleep.
Dizziness, cold and clammy skin.

Other Physical Symptoms:

Depression, decreased alertness and muscle control, intoxication and slurred speech, drowsiness


Shallow respiration, cold and clammy skin, dilated pupils, weak and rapid pulse, coma, possible death

Common Barbiturates:

Proprietary (Trade) Name Substance DEA Schedule*
Amytal Amobarbital II
Nembutal Pentobarbital II
Luminal, Mebaral Phenobarbital IV
Seconal Secobarbital II

Further Information

Barbiturates were first introduced for medical use in the early 1900s. More than 2,500 barbiturates have been synthesized, and at the height of their popularity, about 50 were marketed for human use. Today, about a dozen are in medical use. Barbiturates produce a wide spectrum of central nervous system depression, from mild sedation to coma, and have been used as sedatives, hypnotics, anesthetics, and anticonvulsants. The primary differences among many of these products are how fast they produce an effect and how long those effects last. Barbiturates are classified as ultrashort, short, intermediate, and long-acting.

The ultrashort-acting barbiturates produce anesthesia within about one minute after intravenous administration. Those in current medical use are the Schedule IV drug methohexital (Brevital), and the Schedule III drugs thiamyl (Surital) and thiopental (Pentothal). Barbiturate abusers prefer the Schedule II short-acting and intermediate-acting barbiturates that include amobarbital (Amyta), pentobarbital (Nembutal), secobarbital (Seconal), and Tuinal (an amobarbital/secobarbital combination product). Other short and intermediate-acting barbiturates are in Schedule III and include butalbital (Fiorina), butabarbital (Butisol), talbutal (Lotusate), and aprobarbital (Alurate). After oral administration, the onset of action is from 15 to 40 minutes, and the effects last up to six hours. These drugs are primarily used for insomnia and preoperative sedation. Veterinarians use pentobarbital for anesthesia and euthanasia.

Long-acting barbiturates include phenobarbital (Luminal) and mephobarbital (Mebaral), both of which are in Schedule IV. Effects of these drugs are realized in about one hour and last for about 12 hours, and are used primarily for daytime sedation and the treatment of seizure disorders.


Substance: Urine Hair Saliva
Amobarbital 1-3 days N/A N/A
Pentobarbital 1-3 days N/A N/A
Phenobarbital 1-3 weeks N/A N/A
Secobarbital 1-3 days N/A N/A

    *Drug Enforcement Administration (DEA) Schedule I and II drugs have a high potential for abuse. They require greater storage security and have a quota on manufacture among other restrictions. Schedule I drugs are available for research only and have no approved medical use. Schedule II drugs are available only through prescription, cannot have refills and require a form for ordering. Schedule III and IV drugs are available with prescription, may have 5 refills in 6 months and may be ordered orally. Most Schedule V drugs are available over the counter.